A critique of article

Investigating the origin of adenosine triphosphate (ATP) hydrolysis energy (AHE) in water is the article's main hypothesis. The purpose of this article is to identify the source of AHE in water since water can convert ATP into adenosine diphosphate and energy. The prior discoveries have not yet revealed the process of accomplishing AHE from water or the energetics of AHE of water solvent. The article's logical framework for the study project was built on the interactions between the molecular characteristics of water and its electronic states through the use of large-scale simulations that used classical computation and hybrid quantum approaches to determine free energy. The free energy in water was evaluated using the high-accuracy-high-speed method that was developed at Osaka University by Nobuyuki Matubayasi.

The experimental evidence generated from the research article is that hydrolysis free energies of ATP and pyrophosphate mostly -10kcal.mol with insignificant total charges of the solutes. Empirical evidence presented in the article is the new fundamental issue the constancy of AHE as a result of the superb compensation between the electronic state destabilization and stabilization in hydration free energy of the solutes. The presented evidence is a correlational and significant to be described in the standard biology textbooks. The experiment is the correlation between two variables of solvent and solutes, to explain ATP in large-scale using hybrid quantum /classical simulations to measure free energy during stabilization and destabilization states. The research did not eliminate the alternative hypothesis since hydrolysis free energies were insensitive to the total charges of the solutes.
The evaluated reliability ranks at five implying that the experiment to be very reliable in determining the ATP hydrolysis energy from water. Although there are limitations of the research to test the hypothesis which is only carried in the high-accuracy-high-speed method that seems difficult to achieve and sustain, its validity and reliability are high. Other components of the experiment were operated in large-scale simulations of hybrid quantum, and classical computational techniques all of them are expensive to obtain. The evidence of the research is statistically insignificant since the Gibbs free energy of hydrolysis of water ranges from -28 to 34KJ/ mol on standard conditions creating a significant deviation from the -10kcal/mol derived from the experiment. In contrast, one complete hydrolysis of ATP releases 18-18.2 KJ of energy The experiment is practically significant because determinations of the amount of energy liberated depend on the condition settings and varied, and other values are just an approximation. In this experiment, there was no bias determined since there were no more than two trials for comparison. The researcher has been published in ScienceDaily in the professional literature journals. The researchers who succeeded in unveiling the microscopic release of AHE in water are affiliated to Tohoku University and Osaka University. There is no reported conflict of interests reported on the scientists' affiliations and towards the funding sources.
The evaluation of the journal presentation of the scientific research ranks at the scale of 3 based on the information provided in the article. The headline of the research paper is more informative and accurate but the information provided seems not to be comprehensive on how the experiment was conducted. The correlation is well marked, and there is no confusion caused. The new article did not contain any commentary, but further studies towards determining AHE in water and therefore the understanding of ATP hydrolysis energy in water was precisely explained using the large-scale hybrid/classical simulation. The reporter did not list any limitations of the research, and the applicability of the results was not overstated.






Works Cited