the techniques of genetic engineering to reverse antibiotic resistance

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Researchers also created a genetic modification strategy that allows bacteria that are drug-resistant to be deemed drug-susceptible for the first time. This strategy of combating antibiotic resistance seems to be less expensive than other recent drug discovery methods. At the moment, scientists will use biosynthetic bacteria machines to produce antibiotics that give people life (Aydin et al., 2015).
Professor Chaitan Khosla’s lab uses genetic engineers to inject the largest to-date genes into the bacterium Escherichia coli, transforming it into an entity capable of producing significant amounts of erythromycin precursors, a penicillin alternative. To give erythromycin novel properties as well as modify it the genes are re-programed (Baym et al., 2016).

Initially, chemistry was used to alter the erythromycin molecule, an approach that is very costly. Today, the experiment doesn’t apply chemist, and the genes are reprogramed to make erythromycin that is modified. This technique takes a shorter time and is more efficient.

Opportunities for research funding is available through several channels including the research grants. These include the Collaborative Research Programme and the International Center for Genetic Engineering and Biotechnology, a source devoted to financing projects addressing the scientific problems that are original and are of specific importance for the host country as well as regional interest. Host countries benefit in that this reduces the cost of dealing with the disease if a cure is found. Many human lives would be saved (Yosef et al., 2015).

Several people have interest, and their reasons are clear. A successful process would save several human lives. Moreover, individuals would pay less for an efficient treatment. Numerous people would be saved in a year.

There are several significant concerns. One primary care is that the process uses viral vector carrying the functional gene in the body of human beings and until now there it is unknown to where the genes that are functioning are being placed. This might lead to the health situation. Another concern is that the process is irreversible. There are fears that the disease-causing organism might bring a worldwide disaster.

Currently, there are regulations monitoring GMO’s. In the United States, genetically modified organisms are regulated regarding health, safety, as well as environmental legislation that governs unoriginal products. The country’s approach to GMO’s regulation is based on the assumption that management ought to concentrate on the products nature, instead of the production process.

References

Aydin, S., Ince, B., & Ince, O. (2015). Development of antibiotic resistance genes in microbial communities during long-term operation of anaerobic reactors in the treatment of pharmaceutical wastewater. Water research, 83, 337-344.

Baym, M., Stone, L. K., & Kishony, R. (2016). Multidrug evolutionary strategies to reverse antibiotic resistance. Science, 351(6268), aad3292.

Yosef, I., Manor, M., Kiro, R., & Qimron, U. (2015). Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria. Proceedings of the national academy of sciences, 112(23), 7267-7272.

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